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This 68-week, double-blind, placebo-controlled trial produced unprecedented findings: Mean weight loss of 20.4% with the combination compared to 3.0% with placebo 60% of participants achieved at least 20% weight loss , the highest rate observed with any anti-obesity medication 23% achieved at least 30% weight loss , approaching bariatric surgery outcomes Superior to monotherapy with 14.9% weight loss for GLP1 alone and 11.5% for cagrilintide alone Dose flexibility demonstrated with effective weight loss observed even in participants not reaching target doses Investigators noted that the magnitude of weight reduction places this combination in the highest range of pharmaceutical weight-loss interventions, rivaling restrictive bariatric procedures like sleeve gastrectomy in effectiveness